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Jun 22, 2013

Cholera Outbreak in Far Western Region of Nepal

This article linked here in this blog provides us an account of "an outbreak of diarrheal diseases in districts of far-western region of Nepal in late-2009 followed by massive outbreak in Jajarkot district of mid-western region in early-2009. The objective of this study was to explore the causative organism and analyse the sensitivity pattern of the antibiotics in the local context to suggest the use of medicine in future diarrhea outbreak in Nepal. "


Report of Cholera Outbreaks in India


Source: Time of India (TOI)

Time: May - June, 2013

Place: Goa State, central jail at Aguada and the judicial lock-up at Mapusa.

  • 15 prisoners from the central jail were admitted at the Goa Medical College, Bambolim on May 31
  • 128 inmates of central jail at Aguada and the judicial lock-up at Mapusa were sick (last week of May - 1st week of June)
Laboratory Test:
 It is reported that some water samples were taken from the central jail by health services and food and drug administration officials, it tested positive for the E. coli bacteria, which suggest that the drinking water was contaminated by human excreta. However, it is not reported whether fresh / rectal stool examination for Vibrio cholerae was done or not. Nonetheless, the clinicians are pretty sure that the clinical features pointed towards cholera. There was also report of 1 death from acute diarrheal illness thus reported.

Jun 20, 2013

Historical report of Cholera outbreaks in Nepal

When I happen to read  an article in the form of report with a title, " Report on the Cholera Epidemic of 1885 in Nepal; with short description of the topography and ihabitats of the valley", it was like time travel back to Rana regime.The author of the article is G H Gimlette, M.D., Residency - Surgeon and published on May 22, 1886. I think, this is the first scientific study and report of any disease outbreak investigation in Nepal. The description of the outbreak is vivid and the demography, geography and the sanitation and hygiene practice of those times are also decribed so clearly.

This article states that the first recorded epidemic of cholera in Nepal took place in 1823 and then next in 1831. Thereafter, there were series of epidemics in Kathmandu valley in 1843, 1856, 1862 and 1887.

Update on GEMS paper discussion

The Journal Club discussion on GEMS paper was interesting wider participation from various department esp. laboratory. However, I have to say that there was lack of participation from  junior scientists. So, there is still room for improvement.

The main idea of Journal club was to bring various experts in one table and discuss on the paper from various perspective and learn from each other.The discussion was interactive and lively with bold questions. I will write more on these questions in later posts.

One important question that I came up durin discussion was related to proportion of cholera cases among MSD < 5 years of children in Bangladesh, India and Pakistan and its relation with oral cholera vaccination.


Jun 16, 2013

On June 19, 2013, we are conducting an important discussion on a paper that was published in a Lancet re: moderate to severe diarrheal illness (MSD). This was a 3 years  multi centre prospective case control study popularly known as the Global Enteric Multicenter Study, GEMS. The main purpose of the study was to find out the burden and aetiology of diarrheal diseases in infants and young children in developing countries.

For more information, please visit the GEMS homepage for links to the study press release, a fact sheet, supplemental country-specific fact sheets, and an infographic summarizing study findings.


Anuj in Himalayas

Hi i am connecting disqus with my blog for healthy interaction and open dialogue